The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A
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چکیده
منابع مشابه
Production of Reactive Oxygen Species by Mitochondria
The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and reperfusion. Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes and reduces damage to mitochondria. We asked if ROS generation by intact mitochondria during t...
متن کاملMitochondria and reactive oxygen species.
Copyright © 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/HYPERTENSIONAHA.109.130054 2009;53;885-892; originally published online Apr 27, 2009; Hypertension Francesco Addabbo, Monica Montagnani and Michael S. Goligorsky Mitochondria and Reactiv...
متن کاملMitochondria are a major source of paraquat-induced reactive oxygen species production in the brain.
Paraquat (PQ(2+)) is a prototypic toxin known to exert injurious effects through oxidative stress and bears a structural similarity to the Parkinson disease toxicant, 1-methyl-4-pheynlpyridinium. The cellular sources of PQ(2+)-induced reactive oxygen species (ROS) production, specifically in neuronal tissue, remain to be identified. The goal of this study was to determine the involvement of bra...
متن کاملReactive oxygen species production by potato tuber mitochondria is modulated by mitochondrially bound hexokinase activity.
Potato tuber (Solanum tuberosum) mitochondria (PTM) have a mitochondrially bound hexokinase (HK) activity that exhibits a pronounced sensitivity to ADP inhibition. Here we investigated the role of mitochondrial HK activity in PTM reactive oxygen species generation. Mitochondrial HK has a 10-fold higher affinity for glucose (Glc) than for fructose (KMGlc=140 microM versus KMFrc=1,375 microM). Ac...
متن کاملUpdate on Production of Reactive Oxygen Species by Rboh Production of Reactive Oxygen Species by Plant NADPH Oxidases
NADPH oxidases (NOX) catalyze the production of superoxides, a type of reactive oxygen species (ROS). The dramatic induction of ROS production by human NOX2 in activated blood phagocytic cells and its role in promoting pathogen killing has long motivated research in this area (Babior et al., 2002). In plants, the NOX homologs have been named respiratory burst oxidase homologs (Rboh) and they ar...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2019
ISSN: 0022-3042
DOI: 10.1111/jnc.14654